J 104129 fumarate, Tocris Bioscience™

Description

Potent and selective M3 antagonist

Potent M3 muscarinic receptor antagonist that displays ∽ 120-fold selectivity over M2 receptors (Ki values are 4.2, 19 and 490 nM for human M3, M1 and M2 receptors respectively). Exhibits > 250-fold bronchial selectivity; inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (KB values are 3.3 and 170 nM for rat trachea M3 and rat right atria M2 receptors respectively).

Specifications

• CAS: 257603-40-0
• Molecular Formula: C28H40N2O6
• Quantity: 10 mg
• Synonym: j 104129 fumarate, j104129 fumarate hplc, ?r-?-cyclopentyl-?-hydroxy-n-1-4-methyl-3-pentenyl-4-piperidinyl benzeneacetamide fumarate, alphar-alpha-cyclopentyl-alpha-hydroxy-n-1-4-methyl-3-pentenyl-4-piperidinyl benzeneacetam
• InChI Key: HUCQUCITPHOUAC-DSSYAJFBSA-N
• SMILES: CC(=CCCN1CCC(CC1)NC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C.C(=CC(=O)O)C(=O)O
• IUPAC Name: (E)-but-2-enedioic acid;(2R)-2-cyclopentyl-2-hydroxy-N-[1-(4-methylpent-3-enyl)piperidin-4-yl]-2-phenylacetamide
• Molecular Weight (g/mol): 500.636
• PubChem CID: 56972189
• Formula Weight: 500.63
• Percent Purity: >99%
• Chemical Name or Material: J 104129 fumarate