J 113863, Tocris Bioscience™

Description

Potent CCR1 chemokine receptor antagonist

Potent chemokine receptor 1 (CCR1) antagonist (IC50 values are 0.9 and 5.8 nM for human and mouse CCR1 receptors respectively). Also displays high selectivity for human but not mouse CCR3 receptors (IC50 values are 0.58 and 460 nM respectively). Improves paw inflammation, joint damage and dramatically reduces cell infiltration into joints in collagen-induced arthritis in mice.

Isomer also available.

Specifications

Chemical Identifiers

• CAS: 353791-85-2
• Molecular Formula: C30H37Cl2IN2O2
• Molecular Weight (g/mol): 655.442
• InChI Key: FOAFBMYSXIGAOX-UHFFFAOYSA-N
• Synonym: 1-cyclooct-1-en-1-yl methyl-4-2,7-dichloro-9h-xanthene-9-carbonyl amino-1-ethylpiperidin-1-ium iodide
• PubChem CID: 70296607
• IUPAC Name: 2,7-dichloro-N-[1-(cycloocten-1-ylmethyl)-1-ethylpiperidin-1-ium-4-yl]-9H-xanthene-9-carboxamide;iodide
• SMILES: CC[N+]1(CCC(CC1)NC(=O)C2C3=C(C=CC(=C3)Cl)OC4=C2C=C(C=C4)Cl)CC5=CCCCCCC5.[I-]

• Quantity: 1 mg
• Formula Weight: 655.44
• Percent Purity: >98%
• Chemical Name or Material: J 113863