JNJ 5207852 dihydrochloride, Tocris Bioscience™

Description

High affinity H3 receptor antagonist

High affinity histamine H3 receptor neutral antagonist (pKi values are 8.9 and 9.2 in rat and human respectively). Brain penetrant and orally active. Has 3- and 100-fold higher affinity than thioperamide (Cat. No. 0644) for rat and human H3 receptors respectively. Suppresses slow-wave sleep; exhibits wake-promoting effects in rodent arousal models.

Specifications

Chemical Identifiers

• CAS: 398473-34-2
• Molecular Formula: C20H32N2O
• Molecular Weight (g/mol): 316.489
• InChI Key: PTKHFRNHJULJKT-UHFFFAOYSA-N
• Synonym: unii-4i9ovb1g7d, 4i9ovb1g7d, 1-4-3-piperidinopropoxy benzyl piperidine, 1-4-3-piperidin-1-yl propoxy benzyl piperidine, 1-3-4-piperidin-1-ylmethyl phenoxy propyl piperidine, 1-3-4-piperidin-1-yl methyl phenoxy propyl piperidine, piperidine, 1-3-4-1-piperidinylmethyl phenoxy propyl, jnj 5207852 dihydrochloride
• PubChem CID: 2766326
• IUPAC Name: 1-[3-[4-(piperidin-1-ylmethyl)phenoxy]propyl]piperidine
• SMILES: C1CCN(CC1)CCCOC2=CC=C(C=C2)CN3CCCCC3

• Quantity: 10 mg
• Formula Weight: 389.4
• Percent Purity: >99%
• Chemical Name or Material: JNJ 5207852 dihydrochloride