Thermo Scientific Chemicals Ketoconazole, 98%

Description

Ketoconazole, CAS # 65277-42-1, is a synthetic, broad-spectrum antifungal agent with the ability to inhibit a variety of fungal infections.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Ketoconazole is an imidazole antifungal agent

• It functions by inhibiting synthesis of ergosterol, which is the fungal equivalent of cholesterol

Applications

• Ketoconazole shows fungicide activity against a variety of yeast infections

• It is an inhibitor of CYP3A4, which is necessary for the conversion of lanosterol to ergosterol

• It increases fungal cellular permeability

• It also inhibits endogenous respiration by disrupting membrane phospholipids

• Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone

Specifications

Chemical Identifiers

• CAS: 65277-42-1
• Molecular Formula: C₂₆H₂₈Cl₂N₄O₄
• Molecular Weight (g/mol): 531.44
• InChI Key: XMAYWYJOQHXEEK-SIULDFEJSA-N
• Synonym: ketoconazole
• PubChem CID: 76973198
• IUPAC Name: 2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
• SMILES: CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl

• Melting Point: 148.0°C to 150.0°C
• Loss on Drying: 0.5% max. (80°C, 4 h) (vacuum)
• Infrared Spectrum: Authentic
• Assay Percent Range: 97.5% min. (HPLC)
• Packaging: Glass Bottle
• Quantity: 1 g
• Solubility Information: Solubility in water: almost insoluble. Other solubilities: soluble in methanol,less soluble in ethanol,slightly soluble in dichloromethane or chloroform
• Formula Weight: 531.44
• Percent Purity: 98%
• Chemical Name or Material: Ketoconazole

Safety and Handling

Product Identifier

• Ketoconazole

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 3
• LONG-TERM AQUATIC HAZARD Chronic 1
• ACUTE AQUATIC Acute 1
• Reproductive toxicity Category 1B
• Specific target organ toxicity after repeated exposure Category 2

Hazard Statement

• H400-Very toxic to aquatic life.
• H410-Very toxic to aquatic life with long lasting effects.
• H360F-May damage fertility.
• H373-May cause damage to organs.
• H301-Toxic if swallowed.

Precautionary Statement

• P201-Obtain special instructions before use.
• P264-Wash thoroughly after handling.
• P270-Do not eat, drink or smoke when using this product.
• P273-Avoid release to the environment.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only