Tocris Bioscience™ Klotho-derived peptide 1

TGF-β receptor 2 (TβR2) binding peptide; disrupts the TGF-β/TβR2 interaction

Brand:  Tocris Bioscience™ 7830/1

Product Code. 18023882

Description

Klotho-derived peptide 1 (KP1) is a peptide that binds to TGF-β receptor 2 (TβR2) (Kd = 1.4 μM). It inhibits TGF-β signaling by blocking TGF-β/TβR2 interaction. In mouse models of renal fibrosis, intravenous injection of KP1 results in its specific accumulation in the injured kidneys. It suppresses TGF-β signaling, repressing fibroblast activation and ameliorates kidney fibrosis in vivo.

Specifications

• Gene ID (Entrez): 9365
• Content And Storage: Store at -20°C
• Molecular Weight (g/mol): M.W. (Observed): 3228.48

• Purity: 95%
• Gene Alias: EC 3.2.1, EC 3.2.1.31, KL, klotho, TGFB2, TGFbeta, TGFbeta 2
• Quantity: 1 mg