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KLRG1 Monoclonal Antibody (13F12F2), Super Bright™ 600, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
£133.00 - £325.00
Specifications
| Antigen | KLRG1 |
|---|---|
| Clone | 13F12F2 |
| Concentration | 5 μL/Test |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
Description
Description: This 13F12F2 monoclonal antibody reacts with human killer cell lectin-like receptor subfamily G, member 1 (KLRG1), a type II transmembrane inhibitor receptor of the C-type lectin superfamily that contains an ITIM domain. This inhibitory receptor is expressed on subsets of gamma-delta T cells, NK (CD56dim), CD8+ and CD4+ T Cells. KLRG1 is expressed primarily by cells with an effector/memory phenotype that are short-lived, but capable of immediate effector cell function. Cadherin-E, -N, and -R are ligands for KLRG1. Cadherin/KLRG1 interaction inhibits cytolytic activity and proliferation. The percentage of KLRG1 positive cells can vary considerably, depending on antigen experience. The clones 13F12F2 and 13A2 appear to recognize a similar epitope based on cross-blocking studies.
KLRG1 (Killer cell lectin-like receptor G1, MAFA, 2F1-Ag) is a homodimeric member of the lectin-like type 2 transmembrane receptor family whose members contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. KLRG1 is an inhibitory receptor that is expressed on natural killer (NK) cells and certain T cells. NK cells are involved in the lysis of tumor cells and virus-infected cells, and mediate humoral and cell-mediated immune responses.Specifications
| KLRG1 | |
| 5 μL/Test | |
| Monoclonal | |
| Liquid | |
| RUO | |
| Q96E93 | |
| IgG2a κ | |
| Affinity chromatography | |
| Antibody |
| 13F12F2 | |
| Flow Cytometry | |
| Super Bright 600 | |
| Mouse | |
| Human | |
| 10219 | |
| Primary | |
| 4° C, store in dark, DO NOT FREEZE! |