Tocris™ KYT 0353

Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1)

Brand:  Tocris™ 5026/5

Product Code. 18769216

Description

KYT 0353 is a potent and selective inhibitor of L-type amino acid transporter 1 (LAT1) (IC50 = 60 nM for 14C-leucine uptake in H-29 cells). Also suppreses 14C-leucine uptake in renal proximal tubule cells expressing LAT1 (IC50 = 140 nM). Displays ∽500-fold selectivity for LAT1 over LAT2. Reduces cell viability and induces apoptosis in YD-38 oral cancer cells. Arrests growth in several tumor cell lines. Exhibits growth inhibitory effects on HT-29 cells in vivo.

Specifications

• Chemical Name or Material: O-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine dihydrochloride
• Synonym: JPH 203
• Molecular Formula: C₂₃H₁₉Cl₂N₃O₄.2HCl
• Product Type: Inhibitor

• CAS: 1597402-27-1
• Quantity: 5 mg
• Formula Weight: 545.24
• Purity: 96%