L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals

Description

L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase

• It has tumoricidal activity

Applications

• L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase

• It can be used in anti-tumor studies

• It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins

• It can also inhibit production of pro-inflammatory cytokines

Specifications

Chemical Identifiers

• CAS: 133073-73-1
• Molecular Formula: C20H22N8O5
• Molecular Weight (g/mol): 454.45
• MDL Number: MFCD00150847
• InChI Key: FBOZXECLQNJBKD-UGPWUYPHNA-N
• Synonym: l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrate
• PubChem CID: 45157423
• IUPAC Name: (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrate
• SMILES: CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

• Melting Point: 195°C
• Color: Yellow to Orange
• Infrared Spectrum: Authentic
• Assay Percent Range: 98.5% min. (HPLC)
• Packaging: Glass Bottle
• Quantity: 25 mg
• Merck Index: 14, 5985
• Specific Rotation: + 21.5
• Solubility Information: Solubility in water: insoluble in water. Other solubilities: insoluble in alcohol,chloroform,ether,slightly soluble in dilute hydrochloric acid,soluble in dilute solutions of alkali hydroxides a
• Formula Weight: 454.44
• Percent Purity: 99%
• Physical Form: Crystalline Powder
• Chemical Name or Material: L(+)-Amethopterin hydrate

Safety and Handling

Product Identifier

• L(+)-Amethopterin hydrate

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 3
• Germ cell mutagenicity Category 1B
• Reproductive toxicity Category 1A

Hazard Statement

• H360D-May damage the unborn child.
• H340-May cause genetic defects.
• H301-Toxic if swallowed.

Precautionary Statement

• P201-Obtain special instructions before use.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only