L-Homoarginine hydrochloride, 98%, Thermo Scientific Chemicals

Description

An inhibitor of alkaline phosphatase isoenzymes. It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
An inhibitor of alkaline phosphatase isoenzymes. It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.

Solubility
Soluble in water(50 mg/mL).

Notes
Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents. Refrigerated(2-7°C).

Specifications

Chemical Identifiers

• CAS: 1483-01-8
• Molecular Formula: C7H17ClN4O2
• Molecular Weight (g/mol): 224.689
• MDL Number: MFCD00012622
• InChI Key: YMKBVNVCKUYUDM-JEDNCBNOSA-N
• Synonym: l-homoarginine hydrochloride, s-2-amino-6-guanidinohexanoic acid hydrochloride, l +-homoarginine hydrochloride, h-homoarg-oh.hcl, l-homoarginine hcl, l-+-homoarginine hydrochloride, h-homoarg-oh, h-dl-hcit-oh, h-homoarg-oh hcl, h-har-oh hcl
• PubChem CID: 2723930
• IUPAC Name: (2S)-2-amino-6-(diaminomethylideneamino)hexanoic acid;hydrochloride
• SMILES: C(CCN=C(N)N)CC(C(=O)O)N.Cl

• Melting Point: 213°C to 215°C
• Beilstein: 4016621
• Solubility Information: Soluble in water(50mg/mL).
• Quantity: 1 g
• Formula Weight: 224.69
• Optical Rotation: +18° (c=1 in 1N HCl)
• Percent Purity: ≥98%
• Chemical Name or Material: L-Homoarginine hydrochloride

RUO – Research Use Only