Eurofins DiscoverX LATS2 Protein, Active

Active, N-Terminal GST-tagged, recombinant, human LATS2, amino acid residues 553-end and N-Terminal 6His-tagged, recombinant, human MOBKL1A, full length, for use in Kinase Assays.

Brand:  Eurofins DiscoverX 14-987M

Product Code. 17310884

Description

LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

GenBank NM_014572.2 / GenBank BC038112

Specifications

• Formulation: mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
• Quantity: 250 μg
• Recombinant: Recombinant
• Expression System: Recombinant enzyme expressed in Sf21 insect cells
• Purity or Quality Grade: Combined ≥52%

• Molecular Weight (g/mol): 89 kDa (LATS2) and 30 kDa (MOBKL1A)
• Species: Human
• Protein Tag: N-terminal GST / N-terminal 6His
• Protein Form: Truncated
• Protein: LATS2, active