Lead(IV) acetate, 96% (dry wt.), stab. with 5-10% glacial acetic acid, Thermo Scientific Chemicals

Description

Lead(IV) acetate is an important oxidizing agent and a source of acetyloxy group used in organic synthesis. For example, 1,4-dioxene is prepared from dioxane involving 2-acetoxy-1,4-dioxane as an intermediate. Similarly, it is used for the preparation of bis(trifluoromethyl)diazomethane from hexafluoroacetone hydrazone. It also reacts with alkenes, alcohols having a delta-proton and di-n-butyl d-tartrate to get gamma-lactones, cyclic ethers and n-butyl glyoxylate respectively. It induces the cleavage of 1,2-diols to the corresponding aldehydes or ketones. It is actively involved in the Kochi reaction for the decarboxylation of carboxylic acids to alkyl halides and used as an alternative reagent to bromine in the Hofmann rearrangement.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Lead(IV) acetate is an important oxidizing agent and a source of acetyloxy group used in organic synthesis. For example, 1,4-dioxene is prepared from dioxane involving 2-acetoxy-1,4-dioxane as an intermediate. Similarly, it is used for the preparation of bis(trifluoromethyl)diazomethane from hexafluoroacetone hydrazone. It also reacts with alkenes, alcohols having a delta-proton and di-n-butyl d-tartrate to get gamma-lactones, cyclic ethers and n-butyl glyoxylate respectively. It induces the cleavage of 1,2-diols to the corresponding aldehydes or ketones. It is actively involved in the Kochi reaction for the decarboxylation of carboxylic acids to alkyl halides and used as an alternative reagent to bromine in the Hofmann rearrangement.

Solubility
Soluble in water, ethanol, chloroform, benzene, nitrobenzene, tetrachloroethane, nitric acid, hot acetic acid and hydrochloric acid.

Notes
Air and moisture sensitive. Store in cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with alcohols, strong acids and strong reducing agents.

Specifications

Chemical Identifiers

• CAS: 546-67-8
• Molecular Formula: C8H16O8Pb
• Molecular Weight (g/mol): 447.408
• MDL Number: MFCD00008693
• InChI Key: NVTAREBLATURGT-UHFFFAOYSA-N
• Synonym: lead iv acetate
• PubChem CID: 50931538
• IUPAC Name: acetic acid;lead
• SMILES: CC(=O)O.CC(=O)O.CC(=O)O.CC(=O)O.[Pb]

• Melting Point: 175°C
• Density: 2.28
• Linear Formula: Pb(OOCCH₃)₄
• Quantity: 250 g
• UN Number: UN1616
• Beilstein: 3595640
• Sensitivity: Moisture sensitive
• Merck Index: 14,5423
• Solubility Information: Soluble in water,ethanol,chloroform,benzene,nitrobenzene,tetrachloroethane,nitric acid,hot acetic acid and hydrochloric acid.
• Formula Weight: 443.37
• Percent Purity: 96%
• Assay: (dry wt.)
• Chemical Name or Material: Lead(IV) acetate, stabilized with 5 to 10% glacial acetic acid

Safety and Handling

Product Identifier

• Lead(IV) acetate, stabilized with 5-10% glacial acetic acid

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 4
• LONG-TERM AQUATIC HAZARD Chronic 1
• ACUTE AQUATIC Acute 1
• Reproductive toxicity Category 1A
• Specific target organ toxicity after repeated exposure Category 2

Hazard Statement

• H302-Harmful if swallowed.
• H332-Harmful if inhaled.
• H360Df-May damage the unborn child. Suspected of damaging fertility.
• H373-May cause damage to organs.
• H400-Very toxic to aquatic life.
• H410-Very toxic to aquatic life with long lasting effects.

Precautionary Statement

• P264-Wash face, hands and anyexposed skin thoroughly after handling.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contains : Acetic acid, lead(4+) salt, Acetic acid

RUO – Research Use Only