LIG4 Mouse anti-Human, Clone: 1H6C11, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66705-1-IG-20UL

Product Code. 16828835

Description

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.

Specifications

• Antigen: LIG4
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: P49917
• Gene Symbols: LIG4
• Immunogen: LIG4 Fusion Protein Ag3385
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunofluorescence, Western Blot
• Clone: 1H6C11
• Conjugate: Unconjugated
• Gene: LIG4
• Gene Alias: DNA ligase 4, DNA ligase IV, LIG4, ligase IV, DNA, ATP dependent
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 3981
• Content And Storage: -20°C
• Form: Liquid