Tocris Bioscience™ LL 37

Antimicrobial peptide derivative of human cathelicidin

Brand:  Tocris Bioscience™ 5213/1

Product Code. 18718048

Description

LL 37 is an antimicrobial peptide derivative of human cathelicidin. Induces FPRL1-mediated chemotaxis of human neutrophils, monocytes and T cells in vitro. Promotes wound healing following skin-targeted electroporation of a plasmid encoding hCAP-18/LL-37 in mice. LL 37 reduces SARS-CoV-2 infection by blocking the receptor binding domain of the S1 spike protein (Kd = 11.2 nM) and by binding to ACE2 (Kd = 25.5.nM). LL 37 inhibits SARS-CoV-2 pseudovirion infection (IC50 = 4.74 μg/mL) in vitro and in vivo. Also triggers apoptosis in colon cancer cells. Cell permeable.

Specifications

• Quantity: 1 mg
• Product Type: LL 37
• Molecular Weight (g/mol): 4493.32
• Inhibitors: LL 37

For Research Use Only