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LRRC25 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA556155
This item is not returnable.
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Description
Immunogen sequence: EPSCTVSSAD VDWNAEFSAT CLNFSGLSLS LPHNQSLRAS NVILLDLSGN GLRELPVTFF AHLQKLEVLN VLRNPLSRVD GALAARCDLD LQADCNCALE SWHDIRRDNC SGQKPLLCWD TTSSQHNLSA Highest antigen sequence identity to the following orthologs: Mouse - 52%, Rat - 53%.
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164). Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA. [UniProt]Specifications
LRRC25 | |
Polyclonal | |
Unconjugated | |
LRRC25 | |
leucine rich repeat containing 25; leucine-rich repeat-containing protein 25; LRRC25; MAPA; monocyte and plasmacytoid activated molecule; monocyte and plasmacytoid-activated protein; UNQ6169/PRO20174 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
126364 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry, Western Blot | |
Lot-Specific | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q8N386 | |
LRRC25 | |
Recombinant protein corresponding to Human LRRC25 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only