LRRK2-IN-1, Tocris Bioscience™

Description

Potent and selective LRRK2 inhibitor

Potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2). Inhibits both G2019S mutant and wild-type LRRK2 kinase activity (IC50 values are 6 and 13 nM respectively). Causes dephosphorylation, ubiquitination and degradation of LRRK2. Inhibits IFN-γ-induced monocyte maturation in vitro.

Specifications

Chemical Identifiers

• CAS: 1234480-84-2
• Molecular Formula: C31H38N8O3
• Molecular Weight (g/mol): 570.698
• InChI Key: IWMCPJZTADUIFX-UHFFFAOYSA-N
• Synonym: lrrk2-in-1, lrrk2in1, lrrk2-in1, 2-2-methoxy-4-4-4-methylpiperazin-1-yl piperidine-1-carbonyl phenyl amino-5,11-dimethyl-5h-benzo e pyrimido 5,4-b 1,4 diazepin-6 11h-one, 2-2-methoxy-4-4-4-methylpiperazin-1-yl piperidine-1-carbonyl phenyl-amino-5,11-dimethyl-5h-benzo e pyrimido 5,4-b 1,4 diazepin-6 11h-one, 2-2-methoxy-4-4-4-methylpiperazin-1-yl piperidine-1-carbonyl anilino-5,11-dimethylpyrimido 4,5-b 1,4 benzodiazepin-6-one, 2-2-methoxy-4-4-4-methylpiperazin-1-yl piperidin-1-yl carbonyl phenyl amino-5,11-dimethyl-5,11-dihydro-6h-pyrimido 4,5-b 1,4 benzodiazepin-6-one, 5,11-dihydro-2-2-methoxy-4-4-4-methyl-1-piperazinyl-1-piperidinyl carbonyl phenyl amino-5,11-dimethyl-6h-pyrimido 4,5-b 1,4 benzodiazepin-6-one, lrrk-2in1, lrrk2-tn-1
• PubChem CID: 46843906
• ChEBI: CHEBI:78413
• IUPAC Name: 2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one
• SMILES: CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC

• Quantity: 10 mg
• Formula Weight: 570.09
• Percent Purity: >98%
• Chemical Name or Material: LRRK2-IN-1