Tocris Bioscience™ LYN 1604 dihydrochloride

Potent UNC-51-like kinase 1 (ULK1) agonist

Product Code	Brand	Quantity
18747706	Tocris Bioscience™ 6617/10	10 mg
18748106	Tocris Bioscience™ 6617/50	50 mg

Description

LYN 1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) agonist (EC50 = 18.94 nM). In MDA-MB-231 cells, LYN 1604 induces upregulation of Beclin-1, LC3-I and LC3-II, as well as degradation of p62. LYN 1604 induces cell death (IC50 = 1.66 μM) via the ULK complex involving both autophagy and apoptosis pathway effectors (e.g. ATF3, RAD21, and caspase-3); this effect is reversible by the autophagy inhibitor 3-methyladenine (Cat. No. 3977). LYN 1604 inhibits tumor growth in a mouse xenograft model, decreases bone loss in a mouse model of osteoporosis and reduces the formation of TRAP-positive multinucleated cells.

Specifications

• Chemical Name or Material: 2-[Bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]ethanone dihydrochloride
• CAS: 2310109-38-5
• Target: ULK1
• Molecular Formula: C₃₃H₄₃Cl₂N₃O₂.2HCl

Safety and Handling

Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.