Malononitrile, 99%, Thermo Scientific Chemicals

Description

Crosslinking agent for modification of proteins via amidationMalononitrile is used as a precursor in the preparation of anti-cancer drug, triamterene, adenine, methotrexate, thiamine, acrylic fibers and dyes. It is used in Knoevenagel condensation to prepare 2-chlorobenzalmalononitrile by reacting with 2-chlorobenzaldehyde. It acts as a leaching agent for gold. It is used as a raw material for the Gewald reaction of ketone or aldehyde to produce 2-aminothiophene using elemental sulfur and a base. Further, it plays an important role in the preparation of [1,6]-naphthyridines, gamma-ketoamides, 1,4-dihydropyridine, chromeno[2,3-b]pyridine and dihydro-1,4-dithiepine frameworks.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Crosslinking agent for modification of proteins via amidationMalononitrile is used as a precursor in the preparation of anti-cancer drug, triamterene, adenine, methotrexate, thiamine, acrylic fibers and dyes. It is used in Knoevenagel condensation to prepare 2-chlorobenzalmalononitrile by reacting with 2-chlorobenzaldehyde. It acts as a leaching agent for gold. It is used as a raw material for the Gewald reaction of ketone or aldehyde to produce 2-aminothiophene using elemental sulfur and a base. Further, it plays an important role in the preparation of [1,6]-naphthyridines, gamma-ketoamides, 1,4-dihydropyridine, chromeno[2,3-b]pyridine and dihydro-1,4-dithiepine frameworks.

Solubility
Soluble in water, acetone, acetic acid, chloroform, ethanol, ether and benzene.

Notes
Store in a cool place. Incompatible with strong oxidizing agents, strong reducing agents, strong acids and strong bases.

Specifications

Chemical Identifiers

• CAS: 109-77-3
• Molecular Formula: C3H2N2
• MDL Number: MFCD00001883
• InChI Key: CUONGYYJJVDODC-UHFFFAOYSA-N
• Synonym: malononitrile, dicyanomethane, cyanoacetonitrile, malonic dinitrile, methylene cyanide, dicyanmethane, malonodinitrile, malonic acid dinitrile, methylenedinitrile, methane, dicyano
• PubChem CID: 8010
• ChEBI: CHEBI:33186
• IUPAC Name: propanedinitrile

• Melting Point: 30°C to 34°C
• Density: 1.049
• Boiling Point: 220°C to 222°C
• Flash Point: 112°C (233°F)
• Refractive Index: 1.415
• Quantity: 100 g
• UN Number: UN2647
• Beilstein: 773697
• Merck Index: 14,5711
• Solubility Information: Soluble in water,acetone,acetic acid,chloroform,ethanol,ether and benzene.
• SMILES: C(C#N)C#N
• Molecular Weight (g/mol): 66.063
• Formula Weight: 66.06
• Percent Purity: 99%
• Chemical Name or Material: Malononitrile

Safety and Handling

Product Identifier

• Malononitrile

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 3
• LONG-TERM AQUATIC HAZARD Chronic 1
• ACUTE AQUATIC Acute 1

Hazard Statement

• H301-Toxic if swallowed.
• H311-Toxic in contact with skin.
• H331-Toxic if inhaled.
• H400-Very toxic to aquatic life.
• H410-Very toxic to aquatic life with long lasting effects.

Precautionary Statement

• P273-Avoid release to the environment.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.

Supplemental information

• MIXTURE LIST-Contains : Propanedinitrile

RUO – Research Use Only