Metformin hydrochloride, Tocris Bioscience™

Description

Activator of LKB1/AMPK; antidiabetic agent

Metformin hydrochloride is an antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines via inhibition of mitochondrial complex I (MRC-1). Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2.

Specifications

• CAS: 1115-70-4
• Molecular Formula: C4H12ClN5
• MDL Number: MFCD00012582
• Quantity: 100 mg
• Synonym: metformin hydrochloride, 1,1-dimethylbiguanide hydrochloride, metformin hcl, glucophage, riomet, diabefagos, meguan, metformin monohydrochloride, benofomin, denkaform
• InChI Key: OETHQSJEHLVLGH-UHFFFAOYSA-N
• SMILES: [H+].[Cl-].CN(C)C(=N)N=C(N)N
• IUPAC Name: hydrogen 1-[(diaminomethylidene)amino]-N,N-dimethylmethanimidamide chloride
• Molecular Weight (g/mol): 165.63
• PubChem CID: 14219
• Formula Weight: 165.62
• Percent Purity: >98%
• Chemical Name or Material: Metformin hydrochloride