Thermo Scientific™ MethElute™ Reagent (TMPAH)

Product Code	Brand	Quantity
11507690	Thermo Scientific™ TS-49300	10 mL
11597851	Thermo Scientific™ TS-49301	12 x 1 mL

Description

For accurate, sensitive, on-column methylation and detection by GC analysis use Thermo Scientific™ MethElute™ Reagent (TMPAH). It is ideally suited for the quantitative methylation and detection of barbiturates, sedatives, xanthine bases, phenolic alkaloids, and phenytoin, giving a single quantitative peak for each substance. When the reagent is heated with drug-containing extracts, serum, or urine the drugs containing reactive amino, hydroxyl, and carboxyl functions will be methylated at the reactive sites.

Performance Characteristics

Accuracy comparable or better than the UV/TLC method (GC is superior to UV/TLC when phenobarbitol and phenytoin present)

High precision, with coefficient of variation of 5% or less

High sensitivity; barbiturates deteced down to 0.2 mg/dL

Specifications

• Storage: Room Temperature
• Hazards: Flammable, Toxic
• Standard Concentration: 0.2 M

• For Use With: GC
• Standard Components: Trimethylanilinium hydroxide in Methanol

Safety and Handling

Product Identifier

• methelute

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 1
• Flammable liquid Category 2
• Serious eye damage/eye irritation Category 1
• Specific target organ toxicity after single exposure Category 1

Hazard Statement

• H225-Highly flammable liquid and vapour.
• H300-Fatal if swallowed.
• H310-Fatal in contact with skin.
• H331-Toxic if inhaled.
• H318-Causes serious eye damage.
• H370-Causes damage to organs.

Precautionary Statement

• P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
• P264-Wash hands thoroughly after handling.
• P262-Do not get in eyes, on skin, or on clothing.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P370+P378-In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P310-Immediately call a POISON CENTER/doctor/.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P403+P233-Store in a well-ventilated place. Keep container tightly closed.
• P403+P235-Store in a well-ventilated place. Keep cool.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : methyl alcohol, N,N,N-trimethylaniliniumiodide

For Research Use Only. Not for use in diagnostic procedures.