Methoxycarbonylsulfenyl chloride, 95%, Thermo Scientific Chemicals

Description

Methoxycarbonylsulfenyl chloride is used to prepare 3-[(methoxycarbonyl)dithio]-L-alanine by reacting with L-cysteine. Further, it is used in the synthesis of 3-2 pyridinyldithio propanoic acid hydrazide (PDPH). It serves as an important heterobifunctional crosslinker, which is a crosslinker used to make macromolecule-drug conjugates.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Methoxycarbonylsulfenyl chloride is used to prepare 3-[(methoxycarbonyl)dithio]-L-alanine by reacting with L-cysteine. Further, it is used in the synthesis of 3-2 pyridinyldithio propanoic acid hydrazide (PDPH). It serves as an important heterobifunctional crosslinker, which is a crosslinker used to make macromolecule-drug conjugates.

Solubility
Miscible with dichlormethane.

Notes
Moisture sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 26555-40-8
• Molecular Formula: C2H3ClO2S
• Molecular Weight (g/mol): 126.554
• MDL Number: MFCD00013648
• InChI Key: TXJXPZVVSLAQOQ-UHFFFAOYSA-N
• Synonym: methoxycarbonylsulfenyl chloride, methoxycarbonyl sulfenyl chloride, s-chloro o-methyl thiocarbonate, thiocarbonic acid, anhydrosulphide with methyl thiohypochlorite, carbonothioic acid, anhydrosulfide with thiohypochlorous acid, methyl ester, acmc-209gs8, methoxycarbonylsulfenylchloride, chlorothio methoxy oxomethane, methoxy carbonylsulfenyl chloride, methoxy-carbonylsulfenyl chloride
• PubChem CID: 123417
• IUPAC Name: methyl chlorosulfanylformate
• SMILES: COC(=O)SCl

• Density: 1.398
• Boiling Point: 73°C to 74°C (100 mmHg)
• Flash Point: 54°C (129°F)
• Refractive Index: 1.482
• Quantity: 1 g
• UN Number: UN2920
• Beilstein: 1849908
• Sensitivity: Moisture sensitive
• Solubility Information: Miscible with dichlormethane.
• Formula Weight: 126.56
• Percent Purity: 95%
• Chemical Name or Material: Methoxycarbonylsulfenyl chloride

RUO – Research Use Only