Methylene Blue trihydrate, Thermo Scientific Chemicals

Description

Sensitive stain for RNA and ribonuclease

Methylene Blue trihydrate finds many uses in biology and chemistry. It acts as a GCS inhibitor, biological stain and redox indicator. It inhibits tau filament formation. Further, it is reported to bind to the M2 subtype of muscarinic receptors in rat cardiac myocytes and thus exhibit antimuscarinic effects on IK, ACh and ICa. It also inhibits endothelium-dependent relaxation of isolated blood vessels.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Methylene Blue trihydrate finds many uses in biology and chemistry. It acts as a GCS inhibitor, biological stain and redox indicator. It inhibits tau filament formation. Further, it is reported to bind to the M2 subtype of muscarinic receptors in rat cardiac myocytes and thus exhibit antimuscarinic effects on IK, ACh and ICa. It also inhibits endothelium-dependent relaxation of isolated blood vessels.

Solubility
Soluble in water, alcohol and chloroform. Insoluble in ether.

Notes
Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 7220-79-3
• Molecular Formula: C16H24ClN3O3S
• Molecular Weight (g/mol): 373.90
• MDL Number: MFCD00150008
• InChI Key: XQAXGZLFSSPBMK-UHFFFAOYSA-M
• Synonym: C.I. 52015; Basic Blue 9
• PubChem CID: 104827
• IUPAC Name: [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride;trihydrate
• SMILES: O.O.O.[Cl-].CN(C)C1=CC2=[S+]C3=CC(=CC=C3N=C2C=C1)N(C)C

• Beilstein: 3599847
• Merck Index: 14,6060
• Solubility Information: Soluble in water,alcohol and chloroform; Insoluble in ether.
• Formula Weight: 373.90 (319.86 Anhydrous)
• Odor: Odorless
• Color: Green
• Quantity: 100 g
• Physical Form: Crystalline Powder
• Chemical Name or Material: Methylene Blue trihydrate

Safety and Handling

Product Identifier

• Methylene Blue trihydrate

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4

Hazard Statement

• H302-Harmful if swallowed.

Precautionary Statement

• P264-Wash face, hands, and anyexposed skin thoroughly after handling.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contains : Methylene blue trihydrate

RUO – Research Use Only