Thermo Scientific Chemicals Mitomycin C, contains 2 mg Mitomycin C and 48 mg NaCl

Mitomycin C, CAS # 50-07-7, is a methylazirinopyrroloindoledione complex isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. It is a versatile and potent compound with antibiotic activity and may have potential therapeutic value in the treatment of cancer.

Brand:  Thermo Scientific Chemicals 226940020

Product Code. 10286710

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• Mitomycin C is a water soluble, blue-violet crystalline powder, unstable in light and acidic conditions, but may be stably stored at 2-8°c
• Bio-reduced mitomycin C generates oxygen radicals, alkylates DNA, and produces inter-strand DNA cross-links, thereby inhibiting DNA synthesis

Applications

• Mitomycin C is preferentially toxic to hypoxic cells that are resistant to cancer therapy, and is therefore used to study its potential therapeutic effect on advanced stages of cancer
• At high concentrations, mitomycin C inhibits RNA and protein synthesis and demonstrates strong antibiotic properties towards both Gram-positive and Gram-negative bacteria

Specifications

• Chemical Name or Material: Mitomycin C
• Melting Point: >360.0°C
• Packaging: Ampoule
• MDL Number: MFCD00078109
• Merck Index: 15, 6300
• Solubility Information: Solubility in water: soluble. Other solubilities: soluble in methanol, acetone, butyl acetate and, cyclohexanone;, slightly soluble in benzene, ccl4, diethyl ether;, practically insoluble in petroleum ether.
• SMILES: CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
• PubChem CID: 5746
• Formula Weight: 334.32
• Physical Form: Powder

• CAS: 50-07-7, 7647-14-5
• Color: Blue-Violet
• Molecular Formula: C₁₅H₁₈N₄O₅
• Quantity: 2 mg
• Synonym: mitomycin c, mitomycin, ametycine, mutamycin, ametycin, mitocin-c, mitomycinum, mytomycin, mytozytrex, mitomycin-c
• InChI Key: NWIBSHFKIJFRCO-WUDYKRTCSA-N
• Molecular Weight (g/mol): 334.32
• ChEBI: CHEBI:27504
• Percent Purity: ≥99% with regard to the non-formulated material

Safety and Handling

Product Identifier

• Mitomycin C

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Carcinogenicity Category 2

Hazard Statement

• H351-Suspected of causing cancer.
• H302-Harmful if swallowed.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.

RUO – Research Use Only