(+)-MK 801 maleate, Tocris Bioscience™

Description

Non-competitive NMDA antagonist; acts at ion channel site

(+)-MK 801 maleate is a high affinity (Ki = 37.2 nM), selective and non-competitive NMDA receptor antagonist. (+)-MK 801 maleate acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux. It is an effective anti-ischemic agent in several animal models. (+)-MK 801 maleate increases motor activity in rat models. (+)-MK 801 maleate inhibits proliferation and increases apoptosis in hippocampal neural stem cells (NSCs). (+)-MK 801 maleate induces schizophrenia-like symptoms in rodents.

(-)-enantiomer also available.

Specifications

Chemical Identifiers

• CAS: 77086-22-7
• Molecular Formula: C20H19NO4
• Molecular Weight (g/mol): 337.375
• InChI Key: QLTXKCWMEZIHBJ-PJGJYSAQSA-N
• Synonym: dizocilpine maleate, +-mk-801 hydrogen maleate, +-mk 801 maleate, dizocilpine hydrogen maleate, unii-6lr8c1b66q, dizocilpine maleate usan, dsstox_cid_25785, dsstox_rid_81126
• PubChem CID: 6420042
• SMILES: CC12C3=CC=CC=C3CC(N1)C4=CC=CC=C24.C(=CC(=O)O)C(=O)O

• Quantity: 10 mg
• Formula Weight: 337.37
• Percent Purity: >99%
• Chemical Name or Material: (+)-MK 801 maleate