ML SA1, Tocris Bioscience™

Description

Activator of TRPML channels

Activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.

Specifications

Chemical Identifiers

• CAS: 332382-54-4
• Molecular Formula: C22H22N2O3
• Molecular Weight (g/mol): 362.429
• InChI Key: KDDHBJICVBONAX-UHFFFAOYSA-N
• Synonym: ml sa1, 2-2-oxo-2-2,2,4-trimethyl-3,4-dihydroquinolin-1 2h-yl ethyl-1h-isoindole-1,3 2h-dione, ml-sa1, 2-2-oxo-2-2,2,4-trimethyl-3,4-dihydroquinolin-1-yl ethyl isoindole-1,3-dione, 2-2-oxo-2-2,2,4-trimethyl-3,4-dihydroquinolin-1 2h-yl ethyl isoindoline-1,3-dione, 2-2-oxo-2-2,2,4-trimethyl-3,4-dihydro-2h-quinolin-1-yl-ethyl-isoindole-1,3-dione, cbmicro_009667, d0v2co, regid_for_cid_2880983, 2-2-keto-2-2,2,4-trimethyl-3,4-dihydroquinolin-1-yl ethyl isoindoline-1,3-quinone
• PubChem CID: 2880983
• IUPAC Name: 2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindole-1,3-dione
• SMILES: CC1CC(N(C2=CC=CC=C12)C(=O)CN3C(=O)C4=CC=CC=C4C3=O)(C)C

• Quantity: 50 mg
• Formula Weight: 362.42
• Percent Purity: >99%
• Chemical Name or Material: ML SA1