missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Tocris Bioscience™ MLN 4924
Potent and selective NEDD8 activating enzyme (NAE) inhibitor; cell permeable
£138.23 - £528.06
Specifications
| Chemical Name or Material | [(1 S,2 S,4 R)-4-[4-[[(1 S)-2,3-Dihydro-1 H-inden-1-yl]amino]-7 H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamic acid ester |
|---|---|
| CAS | 905579-51-3 |
| Target | NEDD8 Activating Enzyme E1) |
| Molecular Formula | C21H25N5O4S |
| Purity | 0.98 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18779236
|
Tocris Bioscience™
6499/10 |
10 mg |
£138.23
10mg |
Estimated Shipment: 05-08-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
|
18785656
|
Tocris Bioscience™
6499/50 |
50 mg |
£528.06
50mg |
Estimated Shipment: 05-08-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
MLN 4924 (Tak 924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50 = 4.7 nM). MLN 4924 exhibits selectivity over closely related enzymes UAE, UBA6, SAE, and ATG7 (IC50 = 1.5, 1.8, 8.2, and >10 μM, respectively), and displays minimal activity at adenosine receptors and a panel of 12 cellular kinases. MLN 4924 exhibits cyotoxicity in several human tumor-derived cell lines and causes liver damage in SD rats, when given with TNF-α. It blocks the NEDD8 pathway causing DNA damage in mice bearing HCT-116 xenografts. Cell permeable.Specifications
| [(1 S,2 S,4 R)-4-[4-[[(1 S)-2,3-Dihydro-1 H-inden-1-yl]amino]-7 H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamic acid ester | |
| NEDD8 Activating Enzyme E1) | |
| 0.98 |
| 905579-51-3 | |
| C21H25N5O4S |