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Invitrogen™ Transferrin From Human Serum, Alexa Fluor™ 568 Conjugate

Labeled LDL complexes useful in studying the delivery of up to two Fe³⁺ atoms via receptor-mediated endocytosis

Brand: Invitrogen™ T23365

308.68 GBP valid until 2024-09-28
Use promo code "21626" to get your promotional price.

Product Code. 11540766

£463.00 / 5mg

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For Research Use Only. All usage must comply with product instructions.

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To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21626” to get your promotional price

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Description

Transferrin is a monomeric serum glycoprotein (approx. 80,000 daltons) that binds to a specific receptor on the surface of vertebrate cells and delivers up to two Fe³⁺ atoms via receptor-mediated endocytosis.

Once iron-carrying transferrin proteins are inside endosomes, the acidic environment favors dissociation of iron from the transferrin-receptor complex
Following release of iron, apotransferrin is recycled to plasma membrane, where it is released from its receptor to scavenge more iron
Fluorescent transferrin conjugates can therefore be used with fluorescent LDL to distinguish lysosomally directed and recycling endosomal pathways
Experiments are typically performed by adding fluorescently labeled transferrin to cultured cells and analyzing them by microscopy
Label (Ex/Em): Alexa Fluor 594 (590/617)
Amount: 15mg solid (contains 5mg of transferrin conjugate)
Applications include: Image transferrin receptor dynamics using FRET; Observe receptor trafficking in live cells by confocal laser-scanning microscopy; Investigate events occurring during endosomal acidification; Measure transferrin receptor binding affinity in mammals and parasites

Cell Analysis, Cell Viability, Proliferation and Function, Cellular Imaging, Chromatin Biology, Endocytosis, Exocytosis and Phagocytosis, Immunofluorescence (IF), Immunofluorescence Staining and Detection, RNAi, Epigenetics and Non-Coding RNA Research

Order Info

Shipping Condition: Room Temperature

Specifications

Content And Storage	Store in freezer (-5 to -30°C) and protect from light.
Product Type	Transferrin
Form	Solid
Product Line	Alexa Fluor™
Shipping Condition	Room Temperature
Protein Family	Transferrin

Detection Method	Fluorescence
Dye Type	Alexa Fluor Dyes
pH	7.2
Quantity	5 mg
Excitation/Emission	578/603

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For Research Use Only. Not for use in diagnostic procedures.