Gibco™ Mouse IL-1 beta Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Brand:  Gibco™ 211-11B-01M

Product Code. 30088315

Description

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

Specifications

• Accession Number: P10749
• Formulation: Protein with no preservative
• Molecular Weight (g/mol): 17.5
• Quantity: 2 x 500 μg
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/μg
• Gene Symbol: IL1B
• Conjugate: Unconjugated
• Sequence: MVPIRQLHYR LRDEQQKSLV LSDPYELKAL HLNGQNINQQ VIFSMSFVQG EPSNDKIPVA LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.

• For Use With (Application): Functional Assay, Western Blot, ELISA
• Gene ID (Entrez): 16176
• Name: Mouse IL-1 beta
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: catabolin; cytokine; Hematopoietin 1 (H1); IFN beta inducing factor; il 1 b; IL 1ß; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; IL-1 B; IL1B1; IL1beta; IL-1 beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; Interleukin 1 beta precursor; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; interleukin*1*beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1 b; interleukin-1 beta; interleukin-beta; LAF; lymphocyte proliferation-potentiating factor; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta
• Specific Reactivity: Mouse
• Recombinant: Recombinant
• Form: Lyophilized