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Gibco™ Mouse SCF Recombinant Protein, PeproTech®
E. coli Recombinant Protein
£64.75 - £1922.00
Specifications
Accession Number | P20826 |
---|---|
For Use With (Application) | ELISA, Functional Assay, Western Blot |
Formulation | protein with no preservative |
Gene ID (Entrez) | 17311 |
Molecular Weight (g/mol) | 18.3 |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17820863
|
Gibco™
250-03-100UG |
100 μg |
£416.00
100µg |
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17829952
|
Gibco™
250-03-10UG |
10 μg |
£157.00
10µg |
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17821693
|
Gibco™
250-03-1MG |
1 mg |
£1922.00
1mg |
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17820723
|
Gibco™
250-03-250UG |
250 μg |
£674.00
250µg |
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17801303
|
Gibco™
250-03-2UG |
2 μg |
£64.75
2µg |
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17870513
|
Gibco™
250-03-500UG |
500 μg |
£1156.00
500µg |
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17880823
|
Gibco™
250-03-50UG |
50 μg |
£248.00
50µg |
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Description
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.Specifications
P20826 | |
protein with no preservative | |
18.3 | |
E. coli | |
RUO | |
710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF | |
Mouse | |
Recombinant | |
Lyophilized |
ELISA, Functional Assay, Western Blot | |
17311 | |
Mouse SCF | |
-20°C | |
<1 EU/μg | |
Kitl | |
Unconjugated | |
MKEICGNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV IQLSLSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVLC MEENAPKNIK ESPKRPETRS FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA | |
≥ 98% by SDS-PAGE gel and HPLC analyses. |