Thermo Scientific™ MSTFA and MSTFA + 1% TMCS Silylation Reagent

Product Code	Brand	Standard Components	Quantity
11587670	Thermo Scientific™ TS-48911	MSTFA (N-Methyl-N-trimethylsilyltrifluoroacetamide)	10 g
11786957	Thermo Scientific™ TS-48910	MSTFA (N-Methyl-N-trimethylsilyltrifluoroacetamide)	10 x 1 mL ampules
11507680	Thermo Scientific™ TS-48914	MSTFA (N-Methyl-N-trimethylsilyltrifluoroacetamide)	100 mL
11567851	Thermo Scientific™ TS-48915	MSTFA plus 1% TMCS (2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)-acetamide, Chlorotrimethylsilane)	10 x 1 mL ampules
11597670	Thermo Scientific™ TS-48913	MSTFA (N-Methyl-N-trimethylsilyltrifluoroacetamide)	25 mL

Description

Use Thermo Scientific™ MSTFA and MSTFA + 1% TMCS Silylation Reagent for GC analyses of early eluting compounds that would otherwise be obscured in the chromatogram. MSTFA, the most volatile TMS-amide available, and its byproduct N-methyltrifluoroacetamide typically elute with the solvent front, allowing TMS derivatives of small molecules to be analyzed. Addition of Thermo Scientific™ TMCS aids derivatization of amides, secondary amines, and hindered hydroxyls not derivatized by MSTFA alone.

• Trimethylsilyl donor strength comparable to BSA and BSTFA
• Reacts to replace labile hydrogens on a wide range of polar compounds with a Si(CH₃)₃ group
• Used to prepare volatile and thermally stable derivatives for GC and MS
• Volatile byproduct, N-methyltrifluoroacetamide, has an even lower retention time than MSTFA
• Often TMS derivatives of small molecules can be analyzed when derivatized with MSTFA because the byproducts and the reagent itself usually elute with the solvent front
• Addition of Thermo Scientfic TMCS aids derivatization of amides, secondary amines and hindered hydroxyls not derivatized by MSTFA alone

Specifications

• For Use With: GC/MS
• Hazards: Flammable, Irritant

Safety and Handling

Signal Word

• Warning

Hazard Category

• Flammable liquid Category 3
• Skin corrosion/irritation Category 2
• Serious eye damage/eye irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H226-Flammable liquid and vapour.
• H335-May cause respiratory irritation.

Precautionary Statement

• P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
• P240-Ground/bond container and receiving equipment.
• P241-Use explosion-proof electrical/ventilating/lighting/ equipment.
• P243-Take precautionary measures against static discharge.
• P264-Wash thoroughly after handling.
• P370+P378-In case of fire: Use to extinguish.
• P302+P352-IF ON SKIN: Wash with plenty of water/.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P403+P233-Store in a well-ventilated place. Keep container tightly closed.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : N-methyl-N-(trimethylsilyl)trifluoroacetamide

For Research Use Only. Not for use in diagnostic procedures.