MTM1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA552725

Product Code. 15790671

Description

Immunogen sequence: LDHLYSCRFG TFLFNCESAR ERQKVTERTV SLWSLINSNK EKFKNPFYTK EINRVLYPVA SMRHLELWVN YYIRWNPRIK QQQPNPVEQR YMELLALRDE YIKRLEELQL ANSAKLSDPP TSPSSPSQMM P Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 55%.

Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P.

Specifications

• Antigen: MTM1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MTM1
• Gene Alias: AF073996; CG2; CNM; fb19c01; hypothetical protein LOC560881; im:6903724; mKIAA4176; Mtm; MTM1; MTMX; myotubularin; myotubularin 1; Myotubularin-like protein; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase; wu:fb19c01; X-linked myotubular myopathy gene 1; XLMTM; zgc:123266
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4534
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q13496
• Gene Symbols: MTM1
• Immunogen: Recombinant protein corresponding to Human MTM1
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Research Use Only