N-Hydroxysuccinimide, 98+%, Thermo Scientific Chemicals

Description

N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings.

Solubility
Soluble in water, dimethyl formamide, alcohols and ethyl acetate. Insoluble in cold ether.

Notes
Hygroscopic. Moisture sensitive. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides and strong bases. Store in a cool place.

Specifications

Chemical Identifiers

• CAS: 6066-82-6
• Molecular Formula: C4H5NO3
• Molecular Weight (g/mol): 115.088
• MDL Number: MFCD00005516
• InChI Key: NQTADLQHYWFPDB-UHFFFAOYSA-N
• Synonym: n-hydroxysuccinimide, hosu, 1-hydroxysuccinimide, 2,5-pyrrolidinedione, 1-hydroxy, 1-hydroxy-2,5-pyrrolidinedione, succinimide, n-hydroxy, n-hydroxysuccinimde, n-hydroxysuccinimid, unii-mje3791m4t, ccris 2604
• PubChem CID: 80170
• IUPAC Name: 1-hydroxypyrrolidine-2,5-dione
• SMILES: C1CC(=O)N(C1=O)O

• Melting Point: 94°C to 99°C
• Assay Percent Range: >98%
• Quantity: 25 g
• Beilstein: 113913
• Sensitivity: Hygroscopic
• Solubility Information: Soluble in water,dimethyl formamide,alcohols and ethyl acetate. Insoluble in cold ether.
• Formula Weight: 115.09
• Percent Purity: ≥98%
• Chemical Name or Material: N-Hydroxysuccinimide

Safety and Handling

Product Identifier

• N-Hydroxysuccinimide

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Supplemental information

• MIXTURE LIST-Contains : N-Hydroxysuccinimide

RUO – Research Use Only