N,O-Bis(trimethylsilyl)acetamide, 95%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11342695	Thermo Scientific Alfa Aesar L00183.06	5 g
11352695	Thermo Scientific Alfa Aesar L00183.14	25 g
11362695	Thermo Scientific Alfa Aesar L00183.22	100 g

Description

N,O-Bis(trimethylsilyl)acetamide is used as a regioselective desulfation reagent as well as a preparatory agent for carbohydrate and alcohol trimethylsilyl ethers. It is also used for the derivatization of polar functional groups such as carboxylic acids, phenols, steroids, amines, alcohols, alkaloids and amides. It is employed in the formation of stable trimethylsilyl derivatives. Further, it is used in analytical chemistry for the derivatization of compounds in analysis to increase their volatility and to introduce the trimethylsilyl protecting group in organic synthesis. In addition to this, it is used in the protection of hydroxyl groups in natural products, functional groups in organic intermediates and derivatization reagent for gas chromatography-Mass spectral analysis of phenolic acids in fruits.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
N,O-Bis(trimethylsilyl)acetamide is used as a regioselective desulfation reagent as well as a preparatory agent for carbohydrate and alcohol trimethylsilyl ethers. It is also used for the derivatization of polar functional groups such as carboxylic acids, phenols, steroids, amines, alcohols, alkaloids and amides. It is employed in the formation of stable trimethylsilyl derivatives. Further, it is used in analytical chemistry for the derivatization of compounds in analysis to increase their volatility and to introduce the trimethylsilyl protecting group in organic synthesis. In addition to this, it is used in the protection of hydroxyl groups in natural products, functional groups in organic intermediates and derivatization reagent for gas chromatography-Mass spectral analysis of phenolic acids in fruits.

Solubility
Miscible with many nonpolar and polar aprotic solvents.

Notes
Air and moisture sensitive. Incompatible with strong oxidizing agents, water and acids.

Chemical Identifiers

• CAS: 10416-59-8
• Molecular Weight (g/mol): 203.43
• InChI Key: SIOVKLKJSOKLIF-UHFFFAOYSA-N
• PubChem CID: 6913588

• Molecular Formula: C8H21NOSi2
• MDL Number: MFCD00008270
• Synonym: n,o-bis trimethylsilyl acetamide, trimethylsilyl 1z-n-trimethylsilylethanimidate
• SMILES: CC(O[Si](C)(C)C)=N[Si](C)(C)C

Specifications

• Boiling Point: 71°C to 73°C (35mmHg)
• CAS: 10416-59-8
• MDL Number: MFCD00008270
• Beilstein: 1306669
• Synonym: n,o-bis trimethylsilyl acetamide, trimethylsilyl 1z-n-trimethylsilylethanimidate
• SMILES: CC(O[Si](C)(C)C)=N[Si](C)(C)C
• Molecular Weight (g/mol): 203.43
• Formula Weight: 203.43
• Chemical Name or Material: N,O-Bis(trimethylsilyl)acetamide

• Melting Point: -24°C
• Molecular Formula: C8H21NOSi2
• UN Number: UN2920
• Flash Point: 42°C (107°F)
• InChI Key: SIOVKLKJSOKLIF-UHFFFAOYSA-N
• IUPAC Name: trimethylsilyl (1E)-N-trimethylsilylethanimidate
• PubChem CID: 6913588
• Percent Purity: 95%

Safety and Handling

GHS H Statement
H301-H314-H318-H226
Toxic if swallowed.
Causes severe skin burns and eye damage.
Causes serious eye damage.
Flammable liquid and vapor.

GHS P Statement
P210-P301+P310-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

Danger

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Recommended Storage : 2° to 8°C

RUO – Research Use Only