Naringin, Thermo Scientific Chemicals

Description

A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activity

A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activityNaringin is used to prepare naringin dihydrochalcone, which is about 300-1800 times sweeter than sugar. It is a citrus bioflavonoid reported to inhibit cytochrome P450 monooxygenase activity. It also acts as an inhibitor of cytochrome P450 enzymes. It is employed as an antioxidant, lipid lowering and anticancer agent. In addition to this, it is used in a study to assess aldosterone production by a human adrenocortical cell line and to improve cognitive deficits of Alzheimer's disease.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activityNaringin is used to prepare naringin dihydrochalcone, which is about 300-1800 times sweeter than sugar. It is a citrus bioflavonoid reported to inhibit cytochrome P450 monooxygenase activity. It also acts as an inhibitor of cytochrome P450 enzymes. It is employed as an antioxidant, lipid lowering and anticancer agent. In addition to this, it is used in a study to assess aldosterone production by a human adrenocortical cell line and to improve cognitive deficits of Alzheimer′s disease.

Solubility
Soluble in water, alcohol, acetone and warm acetic acid.

Notes
Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 10236-47-2
• Molecular Formula: C27H32O14
• Molecular Weight (g/mol): 580.54
• MDL Number: MFCD00148888,MFCD00149445,MFCD01461988
• InChI Key: DFPMSGMNTNDNHN-ZPHOTFPESA-N
• Synonym: 4',5,7-Trihydroxyflavanone 7-rhamnoglucoside
• PubChem CID: 74787988
• IUPAC Name: 7-[(2S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
• SMILES: C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2OC2=CC(O)=C3C(=O)C[C@H](OC3=C2)C2=CC=C(O)C=C2)[C@H](O)[C@H](O)[C@H]1O

• Color: White to Yellow
• Quantity: 25 g
• Beilstein: 102012
• Merck Index: 14,6425
• Solubility Information: Soluble in water,alcohol,acetone and warm acetic acid.
• Formula Weight: 580.53
• Physical Form: Powder
• Chemical Name or Material: Naringin

RUO – Research Use Only