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NBI 35965 hydrochloride, Tocris Bioscience™

Product Code. 18075422
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent and selective CRF1 antagonist

Potent and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist (Ki values are 4 and > 10000 nM at CRF1 and CRF2 respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50 values are 7.1 and 6.9 respectively) and attenuates CRF and ACTH production in vivo. Orally active and brain penetrant with anxiolytic activity.

Chemical Identifiers

CAS 603151-83-3
Molecular Formula C21H23Cl3N4
Molecular Weight (g/mol) 437.793
InChI Key LNYUWBPFYXPUIO-RSAXXLAASA-N
Synonym nbi 35965 hydrochloride, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-4-methyl-7,8-dihydro-6h-1,3,6,8a-tetraazaacenaphthylene-hydrogen chloride 1/1, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-7,8-dihydro-4-methyl-6h-1,3,6,8a-tetraazaacenaphthylene hydrochloride
PubChem CID 71433630
SMILES CCC1CN2C3=C(C(=N2)C4=C(C=C(C=C4)Cl)Cl)N=C(C=C3N1CC5CC5)C.Cl

Specifications

Quantity 10 mg
Formula Weight 437.79
Percent Purity >98%
Chemical Name or Material NBI 35965 hydrochloride
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