NBI 35965 hydrochloride, Tocris Bioscience™

Description

Potent and selective CRF1 antagonist

Potent and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist (Ki values are 4 and > 10000 nM at CRF1 and CRF2 respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50 values are 7.1 and 6.9 respectively) and attenuates CRF and ACTH production in vivo. Orally active and brain penetrant with anxiolytic activity.

Specifications

Chemical Identifiers

• CAS: 603151-83-3
• Molecular Formula: C21H23Cl3N4
• Molecular Weight (g/mol): 437.793
• InChI Key: LNYUWBPFYXPUIO-RSAXXLAASA-N
• Synonym: nbi 35965 hydrochloride, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-4-methyl-7,8-dihydro-6h-1,3,6,8a-tetraazaacenaphthylene-hydrogen chloride 1/1, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-7,8-dihydro-4-methyl-6h-1,3,6,8a-tetraazaacenaphthylene hydrochloride
• PubChem CID: 71433630
• SMILES: CCC1CN2C3=C(C(=N2)C4=C(C=C(C=C4)Cl)Cl)N=C(C=C3N1CC5CC5)C.Cl

• Quantity: 10 mg
• Formula Weight: 437.79
• Percent Purity: >98%
• Chemical Name or Material: NBI 35965 hydrochloride