NCL 00017509, Tocris Bioscience™

Description

Potent and reversible NIMA related kinase 2 (Nek2) inhibitor

NCL 00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC50 = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo. In mice bearing pancreatic tumors, NCL 00017509 decreases PD-L1 expression and induces an anticancer immune response.

Specifications

• CAS: 1507367-00-1
• Molecular Formula: C15H12N6O
• Linear Formula: C₁₅H₁₂N₆O
• Quantity: 1 mg
• Synonym: 3-6-ethynyl-9h-purin-2-yl amino benzeneacetamide
• Solubility Information: Soluble to 100mM in DMSO
• InChI Key: CJQGLUJHMXCLQY-UHFFFAOYSA-N
• SMILES: C#CC1=C2C(=NC(=N1)NC3=CC=CC(=C3)CC(=O)N)N=CN2
• IUPAC Name: 2-[3-[(6-ethynyl-7H-purin-2-yl)amino]phenyl]acetamide
• Molecular Weight (g/mol): 292.302
• PubChem CID: 56944360
• Formula Weight: 292.3
• Physical Form: Solid
• Chemical Name or Material: 3-[(6-Ethynyl-9H-purin-2-yl)amino]benzeneacetamide
• Grade: >97%