Neuropilin-1 Recombinant Rabbit Monoclonal Antibody (ARC0488), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen MA535253

Product Code. 17155913

Description

Immunogen sequence: IDETGSTPGY EGEGEGDKNI SRKPGNVLKT LDPILITIIA MSALGVLLGA VCGVVLYCAC WHNGMSERNL SALENYNFEL VDGVKLKKDK LNTQSTYSEA

Neuropilin 1 is a 923 amino acid containing membrane bound coreceptor to a tyrosine kinase receptor belonging to the neuropilin family with two CUB domains, two F5/8 type C domains and a MAM domain. Neuropilin 1 forms a heterodimer with NRP2 (Neuropilin 2) and is known to bind to plexin (PLXNB1) to form semaphorin receptors. Expressed mostly in the nervous system this receptor is implicated in a wide range of functions including in the development of the cardiovascular system, angiogenesis, repulsive axon guidance, formation of certain neuronal circuits, cell survival, control of neuronal migration and organogenesis outside the nervous system. This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis. Neuropilin 1 may be involved in aggressive advanced prostate carcinoma and in the progression of breast cancer.

Specifications

• Antigen: Neuropilin-1
• Classification: Monoclonal
• Concentration: 0.8 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O14786, P97333, Q9QWJ9
• Gene Symbols: NRP1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 824-923 of human Neuropilin-1 (NRP1) (O14786)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Clone: ARC0488
• Conjugate: Unconjugated
• Gene: NRP1
• Gene Alias: A5 protein; BDCA4; C530029I03; CD304; Neuropilin; neuropilin 1; Neuropilin1; neuropilin-1; Neuropilin-1 precursor (A5 protein); NP1; NP-1; Npn1; NPN-1; NRP; NRP 1; Nrp1; sNRP 1; sNRP1; soluble NRP 1; soluble NRP1; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; VEGF165R
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18186, 246331, 8829
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid