Tocris Bioscience™ NICE 01

Heterobifunctional compound for nuclear import of FKBPF36V tagged proteins

Brand:  Tocris Bioscience™ 8088/5

Product Code. 18004932

Description

NICE 01 is a bifunctional molecule consisting of (+)-JQ1 (Cat. No. 4499) and AP 1867 (Cat. No. 6207), with a PEG2-diamine linker. It has a high affinity (Kd = 94 pM) for FKBPF36V tagged proteins. It can induce nuclear localization of cytosolic proteins and target transcriptional regulation. It can be used to calculate the kinetic constant and passive diffusion across the nuclear pore.

Specifications

• Chemical Name or Material: (R)-1-(3-((14-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,13-dioxo-6,9-dioxa-3,12-diazatetradecyl)oxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-
• Target: Protein Dimerizers
• Purity: 98%

• Quantity: 5 mg
• Molecular Formula: C₆₃H₇₆ClN₇O₁₃S