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NKH 477, Tocris Bioscience™

Product Code. 30001270
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Water-soluble adenylyl cyclase activator

Water-soluble analog of forskolin (Cat. No. 1099) that is a potent activator of adenylyl cyclase; shows some selectivity for cardiac (type V) adenylyl cyclase. Stimulates bronchodilation (EC50 = 32.6 nM) and is an orally active potent positive chronotrope and hypotensive agent in vivo.

Chemical Identifiers

CAS 138605-00-2
Molecular Formula C27H43NO8
Molecular Weight (g/mol) 509.64
InChI Key RSOZZQTUMVBTMR-XGUNBQNXSA-N
Synonym colforsin daropate, colforsin dapropate hcl, colforsin dapropate, colforsin daropate hcl, beta-alanine, n,n-dimethyl-, 3r,4ar,5s,6s,6as,10s,10ar,10bs-5-acetyloxy-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1h-naphtho 2,1-b pyran-6-yl ester, 3r,4ar,5s,6s,6as,10s,10ar,10bs-5-acetyloxy-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2h-benzo f chromen-6-yl 3-dimethylamino propanoate
PubChem CID 444029
IUPAC Name [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetyloxy-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-6-yl] 3-(dimethylamino)propanoate
SMILES CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)OC(=O)CCN(C)C

Specifications

Formula Weight 546.1
Percent Purity >98%
Quantity 10 mg
Chemical Name or Material NKH 477
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