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NPHS2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 20384-1-AP-150UL
Additional Details : Weight : 0.00010kg
Description
The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.Specifications
NPHS2 | |
Polyclonal | |
Unconjugated | |
NPHS2 | |
NPHS2, PDCN, Podocin, SRN1 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
170484, 170672, 7827 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot | |
0.22 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q8K4G9, Q91X05, Q9NP85 | |
Nphs2 | |
NPHS2 Fusion Protein Ag14213 | |
150 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |