NS 1643, Tocris Bioscience™

Description

KV11.1 (hERG) channel activator; antiarrhythmic

Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro.

Specifications

Chemical Identifiers

• CAS: 448895-37-2
• Molecular Formula: C15H10F6N2O3
• Molecular Weight (g/mol): 380.246
• InChI Key: NJFVQMRYJZHGME-UHFFFAOYSA-N
• Synonym: 1,3-bis 2-hydroxy-5-trifluoromethyl phenyl urea, unii-0i579cng0i, n,n'-bis 2-hydroxy-5-trifluoromethyl phenyl urea, urea, n,n'-bis 2-hydroxy-5-trifluoromethyl phenyl, 1,3-bis 2-hydroxy-5-trifluoromethylphenyl urea, ns hplc , solid
• PubChem CID: 10177784
• IUPAC Name: 1,3-bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
• SMILES: C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)O)O

• Quantity: 10 mg
• Formula Weight: 380.24
• Percent Purity: >98%
• Chemical Name or Material: NS 1643