Olanzapine, Tocris Bioscience™

Description

5-HT2A/D2 antagonist; atypical antipsychotic

Antagonist of 5-HT2A and dopamine D2 receptors (Ki values are 4 and 11 nM respectively). Also displays affinity for a range of other receptors including D1 and D4, 5-HT2C, α1, H1 and M1-4 receptors (Ki values range between 1.9 and 31 nM) . Atypical antipsychotic. Displays anticholinergic properties. Also a highly potent activator of hM4Di DREADDs (EC50 values are 5 nM in vitro and 7 nM in vivo).

Specifications

Chemical Identifiers

• CAS: 132539-06-1
• Molecular Formula: C17H20N4S
• Molecular Weight (g/mol): 312.44
• MDL Number: MFCD00866702
• InChI Key: WXPNDRBBWZMPQG-UHFFFAOYSA-N
• Synonym: olanzapine, zyprexa, zyprexa zydis, olansek, zalasta, symbyax, zyprexa intramuscular, zyprexa velotab, 2-methyl-4-4-methylpiperazin-1-yl-10h-benzo b thieno 2,3-e 1,4 diazepine, olanzapina
• PubChem CID: 4585
• IUPAC Name: 5-methyl-8-(4-methylpiperazin-1-yl)-4-thia-2,9-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),2,5,7,10,12-hexaene
• SMILES: CN1CCN(CC1)C1=C2C=C(C)SC2=NC2=CC=CC=C2N1

• Quantity: 10 mg
• Formula Weight: 312.43
• Percent Purity: >99%
• Chemical Name or Material: Olanzapine