P 22077, Tocris Bioscience™

Description

USP7 inhibitor

Inhibitor of ubiquitin-specific protease (USP) 7 (EC50 = 8.6 μM); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin in vitro. Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) histone lysine acetyltransferase.

Specifications

Chemical Identifiers

• CAS: 1247819-59-5
• Molecular Formula: C12H7F2NO3S2
• Molecular Weight (g/mol): 315.31
• MDL Number: MFCD22580421
• InChI Key: RMAMGGNACJHXHO-UHFFFAOYSA-N
• Synonym: 1-5-2,4-difluorophenyl thio-4-nitro-2-thienyl-ethanone, 1-5-2,4-difluoro-phenylsulfanyl-4-nitro-thiophen-2-yl-ethanone, 1-5-2,4-difluorophenylthio-4-nitrothiophen-2-yl ethanone, 1-5-2,4-difluorophenyl thio-4-nitrothiophen-2-yl ethan-1-one, 1-5-2,4-difluorophenyl sulfanyl-4-nitrothiophen-2-yl ethan-1-one, 1-5-2,4-difluorophenyl sulfanyl-4-nitrothiophen-2-yl ethanone, 1-5-2,4-difluorophenyl thio-4-nitro-2-thienyl ethanon
• PubChem CID: 46931953
• IUPAC Name: 1-{5-[(2,4-difluorophenyl)sulfanyl]-4-nitrothiophen-2-yl}ethan-1-one
• SMILES: CC(=O)C1=CC(=C(SC2=C(F)C=C(F)C=C2)S1)[N+]([O-])=O

• Quantity: 50 mg
• Formula Weight: 315.32
• Percent Purity: >99%
• Chemical Name or Material: P 22077