p38 MAPK beta Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marque:  Invitrogen PA529302

Code produit. 13423477

Description

Recommended positive controls: 293T, A431, H1299, HeLa, Molt-4, Raji. Predicted reactivity: Mouse (97%), Rat (96%), Bovine (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

MAPK11 (p38 beta) is a serine/threonine kinase which is involved in a variety of cellular processes, and is activated by proinflammatory cytokines and environmental stress. Mitogen-activated protein kinase 11. The protein encoded by p38 MAPK beta is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.

Spécification

• Antigen: p38 MAPK beta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAPK11
• Gene Alias: MAP kinase 11; MAP kinase p38 beta; MAPK 11; Mapk11; mitogen activated protein kinase 11; mitogen-activated protein kinase 11; Mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; OTTHUMP00000196655; p38-2; P38b; p38beta; P38BETA2; Prkm11; protein kinase, mitogen activated kinase, 11, p38beta; SAPK2; SAPK2b; Stress-activated protein kinase 2b; stress-activated protein kinase-2; stress-activated protein kinase-2b
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5600
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.78 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q15759
• Gene Symbols: MAPK11
• Immunogen: Recombinant fragment corresponding to a region within amino acids 148 and 364 of Human p38beta
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG