PAC 1, Tocris Bioscience™

Description

Activator of procaspase-3; pro-apoptotic

Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 μM respectively).

Specifications

Chemical Identifiers

• CAS: 315183-21-2
• Molecular Formula: C23H28N4O2
• Molecular Weight (g/mol): 392.50
• MDL Number: MFCD03302441
• InChI Key: XSGXRYNZNGUGEJ-UHFFFAOYSA-N
• Synonym: pac-1, procaspase-3 activator, procaspase activating compound 1, procaspase-3 activator, pac-1, 4-benzylpiperazino acetic acid-3-allyl-2-hydroxybenzylidene hydrazide, 2-4-benzylpiperazin-1-yl-n'-z-6-oxo-5-prop-2-enylcyclohexa-2,4-dien-1-ylidene methyl acetohydrazide, d01yif, e-n'-3-allyl-2-hydroxybenzylidene-2-4-benzylpiperazin-1-yl acetohydrazide, 2-4-benzylpiperazin-1-yl-n'-1e-2-hydroxy-3-prop-2-en-1-yl phenyl methylidene acetohydrazide, 4-phenylmethyl-1-piperazineacetic acid 2-hydroxy-3-2-propenyl phenyl methylene hydrazide
• PubChem CID: 6851947
• IUPAC Name: 2-(4-benzylpiperazin-1-yl)-N'-{[6-oxo-5-(prop-2-en-1-yl)cyclohexa-2,4-dien-1-ylidene]methyl}acetohydrazide
• SMILES: C=CCC1=CC=CC(=CNNC(=O)CN2CCN(CC3=CC=CC=C3)CC2)C1=O

• Quantity: 50 mg
• Formula Weight: 392.5
• Percent Purity: >98%
• Chemical Name or Material: PAC 1