Tocris Bioscience™ Paroxetine maleate

Highly potent and selective 5-HT uptake inhibitor

Product Code	Brand	Quantity
18083782	Tocris Bioscience™ 2141/10	10 mg
18798566	Tocris Bioscience™ 2141/50	50 mg

Description

Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.

Specifications

• Purity: >99%
• Product Type: Paroxetine maleate
• Molecular Weight (g/mol): 445.44
• Inhibitors: Paroxetine maleate

For Research Use Only