PD 168077 maleate, Tocris Bioscience™

Description

High affinity, selective D4 agonist

A potent D4 dopamine receptor agonist (Ki = 8.7 nM) with > 400-fold selectivity over D2 and > 300-fold selectivity versus D3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo.

Specifications

Chemical Identifiers

• CAS: 630117-19-0
• Molecular Formula: C24H26N4O5
• Molecular Weight (g/mol): 450.495
• InChI Key: NAEUGRPISCANHO-BTJKTKAUSA-N
• Synonym: pd 168077 maleate, pd 168,077 maleate, n-4-2-cyanophenyl piperazin-1-yl methyl-3-methylbenzamide maleate, pd 168,077 maleate salt, n-4-2-cyanophenyl piperazin-1-yl methyl-3-methylbenzamide; maleic acid, n-4-2-cyanophenyl-1-piperazinyl methyl-3-methylbenzamide maleate salt, pd168077 maleate, pd 168,077 maleate salt, powder, n-methyl-4-2-cyanophenyl piperazinyl-3-methylbenzamide maleate, n-4-2-cyanophenyl-1-piperazinyl methyl-3-methyl-benzamide maleate
• PubChem CID: 11957665
• IUPAC Name: (Z)-but-2-enedioic acid;N-[[4-(2-cyanophenyl)piperazin-1-yl]methyl]-3-methylbenzamide
• SMILES: CC1=CC=CC(=C1)C(=O)NCN2CCN(CC2)C3=CC=CC=C3C#N.C(=CC(=O)O)C(=O)O

• Quantity: 10 mg
• Formula Weight: 450.49
• Percent Purity: 98%
• Chemical Name or Material: N-[[4-(2-Cyanophenyl)-1-piperazinyl]methyl]-3-methylbenzamide maleate