Thermo Scientific™ Perfluoroacylimidazoles (TFAI and HFBI) Acylation Reagents

Conduct acylation of hydroxyl groups and primary and secondary amines with the Thermo Scientific™ Perfluoroacylimidazoles (TFAI and HFBI).

Product Code	Brand	Standard Components
11747067	Thermo Scientific™ TS-48882	1-(Trifluoroacetyl)-1 H-imidazole

Description

Conduct acylation of hydroxyl groups and primary and secondary amines with the Thermo Scientific™ Perfluoroacylimidazoles (TFAI and HFBI). Compared to acid chlorides and anhydrides, the reactions of fluorinated acylimidazoles are smooth and quantitative, and produce no acid byproducts. The principal byproduct is imidazole, which is relatively inert. The volatile and stable fluoroacyl derivatives are ideal for FID and electron-capture detection (ECD) techniques.

Applications

Used in bifunctional derivatization schemes and in exchange reactions in which TMS derivatives are converted to HFB derivatives.

Hydroxyl groups of catecholamines are derivatized with TMSI, followed by conversion of the amines to acylamides with HFBI.

Tryptamine and metabolites present in spinal fluid have been analyzed by ECD using HFBI.

Specifications

• For Use With: FID, ECD
• Standard Concentration: 98 to 100%

For Research Use Only. Not for use in diagnostic procedures.