Phleomycin, Fisher BioReagents

Description

Disrupts the integrity of DNA, and blocks S-phase entry in the cell cycle

• An antibiotic often used as selection agent to determine transformation efficiency of algae, fungi, and mammalian cells
• Serves as a selection agent for transformed cells carrying the antibiotic-resistance gene Sh ble
• Causes DNA fragmentation by introducting double-strand breaks in DNA and prevents cells from entering S-phase during the cell cycle

Specifications

• Type: Phleomycin
• Physical Form: Liquid
• Absorbance: 0.75 to 1.05 AU at 244nm
• CAS: 11006-33-0
• Source: Streptomyces verticillus
• Molecular Formula: C51H75N17O21S2
• Odor: None
• Packaging: Plastic Bottle
• InChI Key: QRBLKGHRWFGINE-UGWAGOLRSA-N
• SMILES: CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)(C)OC4C(C(C(C(O4)CO)O)(C(=O)N)O)O)C(=O)NC(C)C(C(C)C(=O)NC(C(=O)C)C(=O)NCCC5=NC(CS5)C6=NC(=CS6)C(=O)N)O
• IUPAC Name: 2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2S,3R,4R,5S)-4-carbamoyl-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)-
• Molecular Weight (g/mol): 1326.379
• PubChem CID: 72511
• Formula Weight: 1526.5
• Sterile Filtered: Pass Test
• Quantity: 100 mg
• Chemical Name or Material: Phleomycin

Safety and Handling

Product Identifier

• Phleomycin, 2% solution in water

Signal Word

• Warning

Hazard Category

• Carcinogenicity Category 2
• Respiratory sensitiser Category 1

Hazard Statement

• H351-Suspected of causing cancer.
• H317-May cause an allergic skin reaction.

Precautionary Statement

• P201-Obtain special instructions before use.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P308+P313-IF exposed or concerned: Get medical advice/attention.