PHLPP Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 22789-1-AP-20UL

Product Code. 16822095

Description

PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.

Specifications

• Antigen: PHLPP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PHLPP1
• Gene Alias: hSCOP, KIAA0606, PHLPP, PHLPP1, PLEKHE1, SCOP
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23239, 98432
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunoprecipitation, Western Blot, Immunofluorescence, Immunohistochemistry (Paraffin)
• Concentration: 0.57 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O60346, Q8CHE4
• Gene Symbols: Phlpp1
• Immunogen: PHLPP Fusion Protein Ag18794
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG