Thermo Scientific™ DTME (dithiobismaleimidoethane)

Crosslink sulfhydryls to sulfhydryls (cysteine residues) with this long, cleavable crosslinker composed of maleimide groups and 11-atom (13.3A) disulfide spacer arm.

Brand:  Thermo Scientific™ 22335

Product Code. 10371314

Description

Thermo Scientific™ Pierce DTME is a mid-length, maleimide crosslinker for reversible covalent conjugation between sulfhydryl groups (e.g., protein or peptide cysteines) by reduction of the disulfide bond in the center of the spacer arm.

Highlights:

• Cleavable by reducing agents
• Reactive groups: maleimide (homobifunctional)
• Reactive toward: sulfhydryl groups

Specifications

• Chemical Reactivity: Sulfhydryl-Sulfhydryl
• Description: DTME
• PEGylated: No
• Content And Storage: Upon receipt store desiccated at 4°C.
• Shipping Condition: Ambient
• Labeling Method: Chemical Labeling
• Reactive Moiety: Maleimide
• Form: Solid
• Solubility: DMF, DMSO
• Water Soluble: No

• Cleavable: By Thiols
• Molecular Weight (g/mol): 312.36
• Spacer Arm Length: 13.3 Å
• Cell Permeability: Yes
• Product Line: Pierce™
• Crosslinker Type: Homobifunctional
• Spacer: Medium (10 to 30 Å)
• Quantity: 50 mg
• Format: Standard
• Product Type: Crosslinker

Safety and Handling

Product Identifier

• DTME (dithiobismaleimidoethane)

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H302-Harmful if swallowed.
• H312-Harmful in contact with skin.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H332-Harmful if inhaled.
• H335-May cause respiratory irritation.

Precautionary Statement

• P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contains : Dithio-BisMaleimidoethane

For Research Use Only. Not for use in diagnostic procedures.